Ammonia → HCID 18939128, compound

HRID 1600203Notes

Reaction equation

HRID 1600203 reaction equation
[NH3:1].[OH:2][C:3]([CH3:19])([CH3:18])[C:4]([C:6]1[CH:17]=[CH:16][C:9]([O:10][CH2:11][C:12](OC)=[O:13])=[CH:8][CH:7]=1)=[O:5]>O1CCOCC1>[OH:2][C:3]([CH3:19])([CH3:18])[C:4]([C:6]1[CH:17]=[CH:16][C:9]([O:10][CH2:11][C:12]([NH2:1])=[O:13])=[CH:8][CH:7]=1)=[O:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18926705HCID 18926705, compound

Product 1

HCID 18939128HCID 18939128, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

75.0 g of 25% strength ammonia are added dropwise with stirring to 25.2 g (0.1 mol) of methyl 4-(2-hydroxy-2-methylpropionyl)phenoxyacetate (obtained by esterifying compound IIg using methanol) in 50 ml of dioxane.After being stirred for 2 hours, the mixture is evaporated to solidification. The crude product is recrystallized from hot water, 22.1 gof compound IIt of melting point 139° C. being obtained.

Workup

  1. customthe mixture is evaporated to solidification
  2. customThe crude product is recrystallized from hot water, 22.1 gof compound IIt of melting point 139° C.
  3. custombeing obtained

Sources & evidence

ORD record
ord-839d99c2d7cf4887b20f30dc4c12c7cb
Source dataset
uspto-grants-1998_04
Patent number
US05744512

Reaction notes

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