Methyl iodide → 3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

HRID 1600234Notes

Reaction equation

HRID 1600234 reaction equation
[CH3:1][I:2].[CH:3]1([CH2:6][O:7][C:8]2[C:12]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[N:11][S:10][N:9]=2)[CH2:5][CH2:4]1>CC(C)=O>[I-:2].[CH:3]1([CH2:6][O:7][C:8]2[C:12]([C:13]3[CH:14]=[N+:15]([CH3:1])[CH:16]=[CH:17][CH:18]=3)=[N:11][S:10][N:9]=2)[CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 190752393-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine

Product 1

HCID 190754673-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of methyl iodide (0.25 ml, 4 mmol) and 3-(3-cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine (400 mg, 1.7 mmol) in acetone (5 ml) was stirred at room temperature for 36 h. The title compound precipitated from the solution and was collected by filtration toyield 0.41 g (65%).

Workup

  1. customThe title compound precipitated from the solution
  2. filtrationwas collected by filtration toyield 0.41 g (65%)

Sources & evidence

ORD record
ord-11b638351e8a40ff925f24e252e958cf
Source dataset
uspto-grants-1998_04
Patent number
US05744489

Reaction notes

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