Methyl iodide → 3-(3-(4-Methylpiperidino)-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

HRID 1600281Notes

Reaction equation

HRID 1600281 reaction equation
[CH3:1][I:2].[CH3:3][CH:4]1[CH2:9][CH2:8][N:7]([C:10]2[C:14]([C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)=[N:13][S:12][N:11]=2)[CH2:6][CH2:5]1>CC(C)=O>[I-:2].[CH3:3][CH:4]1[CH2:5][CH2:6][N:7]([C:10]2[C:14]([C:15]3[CH:16]=[N+:17]([CH3:1])[CH:18]=[CH:19][CH:20]=3)=[N:13][S:12][N:11]=2)[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 190753173-(3-(4-Methylpiperidino)-1,2,5-thiadiazol-4-yl)pyridine

Product 1

HCID 190753753-(3-(4-Methylpiperidino)-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of methyl iodide (0.5 ml, 8 mmol) and 3-(3-(4-methylpiperidino)-1,2,5-thiadiazol-4-yl)pyridine (0.8 g, 3.1 mmol)in acetone (5 ml) was stirred at room temperature for 18 h. The title compound precipitated from the solution and was collected by filtration toyield 1.14 g (92%).

Workup

  1. customThe title compound precipitated from the solution
  2. filtrationwas collected by filtration toyield 1.14 g (92%)

Sources & evidence

ORD record
ord-4fec0d57ff54434abec49ae355140ef6
Source dataset
uspto-grants-1998_04
Patent number
US05744489

Reaction notes

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