Phosphorus oxychloride → HCID 178466708, compound

HRID 1600346Notes

Reaction equation

HRID 1600346 reaction equation
O[C:2]1[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:12](=[O:25])[N:13]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH3:24])=[CH:18][CH:17]=3)[C:14](=[O:15])[C:3]=12.P(Cl)(Cl)([Cl:28])=O>>[Cl:28][C:2]1[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:12](=[O:25])[N:13]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH3:24])=[CH:18][CH:17]=3)[C:14](=[O:15])[C:3]=12

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178466710HCID 178466710, compound

Product 1

HCID 178466708HCID 178466708, compound

Procedure

A solution of 4-Hydroxy-2-(4-ethoxyphenyl)-imidazo[1,5,a]-quinoxaline-1,3(2H,5H)-dione (3.2 g) in phosphorous oxychloride (40 mL) was refluxed for 16 h. The solvent was removed in vacuo and water (15 mL) was added. The pH was adjusted to 7.0 using ammonium hydroxide and the resulting solid was filtered and dried to yield 4-Chloro-2-(4-ethoxyphenyl)-imidazo[1,5,a]quinoxaline-1,3(2H,5H)-dione (Compound 36).

Workup

  1. customThe solvent was removed in vacuo and water (15 mL)
  2. additionwas added
  3. filtrationthe resulting solid was filtered
  4. customdried

Sources & evidence

ORD record
ord-b13aeb06648c43498e63b1ffcd7682f1
Source dataset
uspto-grants-1998_04
Patent number
US05744602

Reaction notes

Loading…