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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1600351Generated: October 25, 2026

Imidazole → Diethyl 3-(tert-Butyldimethylsilyloxy)glutarate

https://huagongshe.com/reaction/1600351

Reaction equation

Participants

RoleNameHCIDCharge
ReactantImidazoleHCID 795—
Reactanttert-Butyldimethylsilyl chlorideHCID 28928—
ReactantDiethyl 3-hydroxyglutarateHCID 96259—
SolventDichloromethaneHCID 6344—
ProductDiethyl 3-(tert-Butyldimethylsilyloxy)glutarateHCID 13327289—

Reaction Steps

Imidazole and tert-butylchlorodimethylsilane are added to a solution of diethyl 3-hydroxyglutarate in methylene chloride, and the reaction is performed to give diethyl 3-[(tert-butydimethylsilyl)-oxy]pentanedioate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05744604
Source datasetuspto-grants-1998_04
ORD IDord-74225625011f4fc3918d63a785f63c5e
Source noteuspto-grants-1998_04