Triethylamine hydrochloride → HCID 178423709, compound

HRID 1600375Notes

Reaction equation

HRID 1600375 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:14]#[N:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[N-:16]=[N+:17]=[N-:18].[Na+].Cl.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:14]2[NH:18][N:17]=[N:16][N:15]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 1455122-Cyano-4'-methylbiphenyl

Product 1

HCID 178423709HCID 178423709, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Into the same device as used in Example 1 were placed 9.66 g (0.050 mole) of 4'-methylbiphenyl-2-carbonitrile, 6.50 g (0.100 mole) of sodium azide, 13.77 g (0.100 mole) of triethylamine hydrochloride and 96.6 ml of toluene. The mixture was reacted for 48 hours in the same manner as in Example 1, giving 10.85 g (0.046 mole) of 5-(4'-methylbiphenyl-2-yl)-1H-tetrazole (yield 91.9% based on 4'-methylbiphenyl-2-carbonitrile). The reaction is illustrated below with chemical formulas: ##STR26##

Workup

  1. customThe mixture was reacted for 48 hours in the same manner as in Example 1

Sources & evidence

ORD record
ord-01340e80c92a45c998082bc758b328bd
Source dataset
uspto-grants-1998_04
Patent number
US05744612

Reaction notes

Loading…