反应详情

温度

0 °C

Trans-1-diethylphosphonomethoxycyclopent-2-en-4-ol (0.4 g; 1.6 mmol) was dissolved in CH2Cl2 (6 mL) and cooled to 0° C. in an icebath under a nitrogen atmosphere. Triethylamine (0.3 g; 2.9 mmol) was then added followed by a solution of toluenesulfinyl chloride (0.4 g, 2.9 mmol)in CH2Cl2 (2 mL). The reaction mixture was stirred at 0° C. for 1 hr. The ice bath was removed and the reaction mixture concentrated in vacuo. The residual oil was purified by flash column chromotography with 2% methanol/98% dichloromethane as eluent. The product(0.54 g; 87%) was isolated as a colorless oil.

1. customThe ice bath was removed
2. concentrationthe reaction mixture concentrated in vacuo
3. customThe residual oil was purified by flash column chromotography with 2% methanol/98% dichloromethane as eluent
4. customThe product(0.54 g; 87%) was isolated as a colorless oil