化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Boc-L-phenylalanine methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- | HCID 77857 | — |
| 反応物 | Chloromethyl formate | HCID 17803410 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Boc-L-phenylalanine methyl ester | HCID 9882138 | — |
反応手順
To a solution of 8.8 g(0.0344 mol) of N-t-butoxycarbonylphenylalanine in 50ml of dichloromethane were successively added 5.25 ml of triethylamine solution, and 3 ml of chloromethylformate at 0° C. 50 mg of 4-dimethylaminopyridine was added to catalyze the reaction. After the reaction was completed the reaction mixture was extracted with dichloromethane and distilled under a reduced pressure to give the title compound quantitatively.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05744621 |
| 出典データセット | uspto-grants-1998_04 |
| ORD ID | ord-416bb0e6f35a49029d3214ec95ac3944 |
| 出典メモ | uspto-grants-1998_04 |