反应详情

To a solution of 8.8 g(0.0344 mol) of N-t-butoxycarbonylphenylalanine in 50ml of dichloromethane were successively added 5.25 ml of triethylamine solution, and 3 ml of chloromethylformate at 0° C. 50 mg of 4-dimethylaminopyridine was added to catalyze the reaction. After the reaction was completed the reaction mixture was extracted with dichloromethane and distilled under a reduced pressure to give the title compound quantitatively.

1. customat 0° C
2. customthe reaction
3. extractionwas extracted with dichloromethane
4. distillationdistilled under a reduced pressure