HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzonitrile, 4-chloro-3-nitro- → 3-Amino-4-chlorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzonitrile, 4-chloro-3-nitro- | HCID 13655 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Phosphine | HCID 24404 | — |
| Reactant | Trisodium 3,3',3''-phosphinetriyltris(benzene-1-sulphonate) | HCID 6099338 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 3-Amino-4-chlorobenzonitrile | HCID 104464 | — |
Reaction Steps
A degassed solution of 40 mmol of 4-chloro-3-nitrobenzonitrile (starting material) and 40 ml of xylene are placed in an autoclave (volume: 200 ml).5.0 mmol of TPPTS (in the form of 9.2 g of an aqueous solution containing 0.546 mol of TPPTS/kg of solution) as phosphine and 2.4 g (60 mmol) of NaOH, 23.8 ml of H2O and 1.0 mmol of PdCl2 are added. The pH isfrom 10.5 to 11.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05744643 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-e5d7b1495f414d6689cfe3e2ff5eb883 |
| Source note | uspto-grants-1998_04 |