Ethanolamine → 2-((Triphenylmethyl)amino)ethanol

HRID 1600436Notes

Reaction equation

HRID 1600436 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].[C:5](Cl)([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.N1C=CC=CC=1>O>[C:5]([NH:4][CH2:3][CH2:1][OH:2])([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 700EthanolamineHCID 1049PyridineHCID 6456Trityl chloride

Product 1

HCID 31256082-((Triphenylmethyl)amino)ethanol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of ethanolamine, trityl chloride and pyridine was refluxed for 15h. Water was added slowly to the cooled reaction and the precipitate collected by filtration. The crude product recrystallized from a 1:1 mixture of ethanol and water.

Workup

  1. temperaturewas refluxed for 15h
  2. filtrationthe precipitate collected by filtration
  3. customThe crude product recrystallized from a 1:1 mixture of ethanol and water

Sources & evidence

ORD record
ord-37cb733aaaa64903931dd2bc0c489f04
Source dataset
uspto-grants-1998_04
Patent number
US05744592

Reaction notes

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