2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid → Benzoic acid, 2-(3,6-dihydroxy-9H-xanthen-9-yl)-

HRID 1600524Notes

Reaction equation

HRID 1600524 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([C:23]([OH:25])=[O:24])=[C:5]([C:7]2[C:17]3[CH:18]=[CH:19][C:20]([OH:22])=[CH:21][C:16]=3[O:15][C:14]3[C:8]=2[CH:9]=[CH:10][C:11]([CH:13]=3)=[O:12])[CH:6]=1.[OH-].[Na+]>[Zn]>[CH:1]1[CH:2]=[CH:3][C:4]([C:23]([OH:25])=[O:24])=[C:5]([CH:7]2[C:17]3[CH:18]=[CH:19][C:20]([OH:22])=[CH:21][C:16]=3[O:15][C:14]3[CH:13]=[C:11]([OH:12])[CH:10]=[CH:9][C:8]2=3)[CH:6]=1

Participants

4

Reactant 2

HCID 33832-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acidHCID 14798Sodium Hydroxide

Product 1

HCID 68205Benzoic acid, 2-(3,6-dihydroxy-9H-xanthen-9-yl)-

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

According to another aspect of the invention, there is provided a method of producing an aqueous fluorescin solution, in which about 1 g of fluorescein is mixed with about 100 ml of a 10% sodium hydroxide aqueous solution and heated in the presence of about 10 g of zinc to produce a colorless fluorescin solution, wherein the improvement of the method includes heating the mixture of fluorescein and 10% sodium hydroxide aqueous solution with about 20 mesh zinc particles to about boiling in a non-refluxing container to produce a nearly colorless fluorescin solution containing zinc particles, and decanting the colorless fluorescin solution from the zinc particles.

Workup

  1. temperatureincludes heating

Sources & evidence

ORD record
ord-d1397b47df2045b5b4fbf2cfd12ba112
Source dataset
uspto-grants-1999_11
Patent number
US05976886

Reaction notes

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