Sodium Hydroxide → HCID 21829895, compound

HRID 1600529Notes

Reaction equation

HRID 1600529 reaction equation
[CH3:1][C:2]([N:9]1[C:14](=[O:15])[C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:12]([CH3:22])[O:11][CH2:10]1)([CH2:7][CH3:8])[C:3]([O:5]C)=[O:4].[OH-].[Na+]>C(O)C>[CH3:1][C:2]([N:9]1[C:14](=[O:15])[C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:12]([CH3:22])[O:11][CH2:10]1)([CH2:7][CH3:8])[C:3]([OH:5])=[O:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15456866HCID 15456866, compound

Product 1

HCID 21829895HCID 21829895, compoundYield 74.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of methyl 2-methyl-2-(6-methyl-5-phenyl-2, 3-dihydro-4-oxo-4 H-1,3-oxazin-3-yl)-butyrate (1.91 g) in 20 ml of ethanol was added at room temperature 30 ml of aq. NaOH (0.3N). After stirring for 24 h, ethanol was evaporated, and the mixture was acidified by hydrochloric acid. The precipitate was filtered off and dried to get the captioned compound (1.36 g).

Workup

  1. customethanol was evaporated
  2. filtrationThe precipitate was filtered off
  3. customdried

Sources & evidence

ORD record
ord-fd3446a511444dd896718be1ca87c5f1
Source dataset
uspto-grants-1999_11
Patent number
US05977025

Reaction notes

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