1-Butanol → Butyl chloromethyl carbonate

A solution of butyl alcohol (50 mmol) and chloromethyl chloroformate (4.5 mL, 50 mmol) in diethyl ether (200 mL) was cooled to 0° C. under argon. Pyridine (5.7 mL, 50 mmol) was added dropwise with stirring over 5 min. The solution was stirred at 0° C. for 15 min, then allowed to warm to room temperature and stirred for three additional hours. The ether solution was filtered, washed with 1 M HCl, and then twice with water, dried over MgSO4, filtered, and concentrated on a rotary evaporator to give butyl chloromethyl carbonate (7 g, 85%).

1. stirringThe solution was stirred at 0° C. for 15 min
2. stirringstirred for three additional hours
3. filtrationThe ether solution was filtered
4. washwashed with 1 M HCl
5. dry with materialtwice with water, dried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated on a rotary evaporator

ORD record

ord-4a08ef4ee5064e45a7ea63beb414c928

Source dataset

uspto-grants-1999_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05977089