HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Chloride → Ethyl 5-(4-benzyl-1-piperazinyl)benzofuran-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Ethyl 5-(piperazin-1-yl)benzofuran-2-carboxylate | HCID 11266913 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 5-(4-benzyl-1-piperazinyl)benzofuran-2-carboxylate | HCID 23508728 | — |
Reaction Steps
A solution of 1 g of ethyl 5-(1-piperazinyl)-benzofuran-2-carboxylate in 50 ml of dichloromethane is treated with 1 g of benzyl chloride and stirred for 2 hours. After customary working up, ethyl 5-(4-benzyl-1-piperazinyl)benzofuran-2-carboxylate, m.p. 219-222°, is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977112 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-a684259b6fa9438da29e560c0abb2613 |
| Source note | uspto-grants-1999_11 |