Potassium Carbonate → HCID 21189944, compound

HRID 1600759Notes

Reaction equation

HRID 1600759 reaction equation
[Cl:1][C:2]1[C:7]([CH2:8][CH3:9])=[CH:6][C:5]([N+:10]([O-:12])=[O:11])=[C:4]([NH:13]C(=O)C(F)(F)F)[CH:3]=1.C([O-])([O-])=O.[K+].[K+]>CO.O.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]([N+:10]([O-:12])=[O:11])=[CH:6][C:7]=1[CH2:8][CH3:9])[NH2:13]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 21189974HCID 21189974, compound

Product 1

HCID 21189944HCID 21189944, compoundYield 73.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 22242641Methanol--water (1/1)Solvent

Procedure

A mixture of 1.4 g (4.7 mmol) of 33 and 10 mL of 7% K2CO3 in methanol/H2O (3:2) was stirred at room temperature for 2 h. It was diluted with 15 mL of water, filtered, washed with water, and dried to leave 691 mg (73%) of a yellow solid; mp 100-101° C.; (Lit. 104-106° C. Lambooy & Lambooy, supra). 1H NMR (CDCl3), 1.228 (t, 3, J=7.5), 2.665 (q, 2, J=7.5), 5.957 (sb, 2), 6.859 (s, 1), 7.995 (s, 1).

Workup

  1. filtrationfiltered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-077572c76d054e05a918ef548a96eec6
Source dataset
uspto-grants-1999_11
Patent number
US05977107

Reaction notes

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