HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Benzyl-1-[2-(2-fluorophenyl)propanoyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 2-(2-Fluoro-phenyl)-propionic acid | HCID 18421588 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Benzyl-1-[2-(2-fluorophenyl)propanoyl]piperazine | HCID 21830856 | 38% |
Reaction Steps
2-(2-Fluorophenyl)propanoic acid (7.7 g, 0.046 mol), 1-benzylpiperazine (8.0 g, 0.045 mol), triethylamine (4.6 g, 0.046 mol) and 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (9.6 g, 0.050 mol) were dissolved in dichloromethane (150 ml) and stirred at room temperature for 18 h. The solution was evaporated and the residue diluted with water and extracted with brine, dried and evaporated. Chromatography on silica gel with dichloromethane-methanol (97:3) yielded 4-benzyl-1-[2-(2-fluorophenyl)propanoyl]piperazine (5.54 g, 38%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977116 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-170de012ad3c4b81969daf35188024b9 |
| Source note | uspto-grants-1999_11 |