Trifluoroacetic acid → HCID 57120183, compound

HRID 1600900Notes

Reaction equation

HRID 1600900 reaction equation
FC(F)(F)C(O)=O.C([O:12][C:13]([CH:15]1[CH2:19][CH2:18][C:17](=[O:20])[N:16]1[C:21](=[O:30])[C:22](=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:14])(C)(C)C>ClCCl>[O:20]=[C:17]1[N:16]([C:21](=[O:30])[C:22](=[O:29])[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C@H:15]([C:13]([OH:14])=[O:12])[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53807532HCID 53807532, compound

Product 1

HCID 57120183HCID 57120183, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (40 ml) was added to a solution of 5-oxo-1-(2-oxo-2-phenylacetyl)pyrrolidine-2-carboxylic acid tert-butyl ester (5.00 g) in dichloromethane (40 ml) and the solution was stirred for 2 hours. All volatiles were removed under reduced pressure and the residue triturated with ether:hexane (1:1). The white solid was collected by filtration and washed with hexane to give the sub-title compound (4.09 g).

Workup

  1. customAll volatiles were removed under reduced pressure
  2. customthe residue triturated with ether:hexane (1:1)
  3. filtrationThe white solid was collected by filtration
  4. washwashed with hexane

Sources & evidence

ORD record
ord-2869393451834c81baa2de046d244651
Source dataset
uspto-grants-1999_11
Patent number
US05977105

Reaction notes

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