Sodium Hydroxide → (+/-)-1-(3'-Chlorobiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

HRID 1600910Notes

Reaction equation

HRID 1600910 reaction equation
Cl[CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.[Cl:13][C:14]1[CH:15]=[C:16]([C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)[CH:17]=[CH:18][CH:19]=1.[OH-].[Na+]>C(O)C>[Cl:13][C:14]1[CH:15]=[C:16]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]3[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=3)=[CH:22][CH:21]=2)[CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 144680054-(3-Chlorophenyl)phenolHCID 22465338HCID 22465338, compound

Product 1

HCID 21830621(+/-)-1-(3'-Chlorobiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared according to the method described in Example 24b) from (±)-α-(chloromethyl)-3-pyridinepropanol (1.0 g), 3'-chlorobiphenyl-4-ol (1.4 g), ethanol (30 ml) and aqueous sodium hydroxide (1.5 M, 5 ml) to give the title compound after purification as a white solid (0.34 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5cd02a25f8794cbb8ea7f57fab454624
Source dataset
uspto-grants-1999_11
Patent number
US05977105

Reaction notes

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