反应详情

Solid 4-methoxy-3'-nitrobiphenyl (1.63 g) was dissolved in acetic acid (25 ml) and then concentrated hydrobromic acid (48%, 25 ml) was added (CAUTION). The mixture was heated at reflux for 2 hours and was then cooled. The reaction mixture was partitioned between ether and water. The organic layer was dried over anhydrous magnesium sulfate, the solution filtered and concentrated under reduced pressure. The residue was purified by column chromatography over silica eluting with hexane:ether (9:1) to give the sub-title compound as a yellow oil (1.44 g).

1. temperatureThe mixture was heated
2. temperatureat reflux for 2 hours
3. temperaturewas then cooled
4. customThe reaction mixture was partitioned between ether and water
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. filtrationthe solution filtered
7. concentrationconcentrated under reduced pressure
8. customThe residue was purified by column chromatography over silica eluting with hexane:ether (9:1)