Boron tribromide → 4-(1,3-Thiazol-2-yl)phenol

HRID 1600956Notes

Reaction equation

HRID 1600956 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 112984492-(4-Methoxy-phenyl)-thiazole

Product 1

HCID 2238404-(1,3-Thiazol-2-yl)phenol

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
-78 °C

Procedure

Prepared according to the method described in Example 36b) from 2-(4-methoxyphenyl)thiazole (1.7 g), dichloromethane (20 ml) and boron tribromide (1.0 M in dichloromethane, 17.8 ml) with stirring at -78° C. After work up the residue was triturated with ether to give the sub-title compound a pale yellow solid (1.2 g).

Workup

  1. customPrepared
  2. customAfter work up the residue was triturated with ether

Sources & evidence

ORD record
ord-8619ce348643452fb449d8cd8f67af90
Source dataset
uspto-grants-1999_11
Patent number
US05977105

Reaction notes

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