Ethanol → (+/-)-4-(3-Pyridyl)-1-(4-(thiazol-2-yl)phenoxy)-2-butanol

HRID 1600957Notes

Reaction equation

HRID 1600957 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.C(O)C.[OH-].[Na+].Cl[CH2:19][CH:20]([OH:29])[CH2:21][CH2:22][C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1>O>[N:25]1[CH:26]=[CH:27][CH:28]=[C:23]([CH2:22][CH2:21][CH:20]([OH:29])[CH2:19][O:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[S:9][CH:10]=[CH:11][N:12]=3)=[CH:6][CH:7]=2)[CH:24]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 2238404-(1,3-Thiazol-2-yl)phenolHCID 22465338HCID 22465338, compound

Product 1

HCID 21830668(+/-)-4-(3-Pyridyl)-1-(4-(thiazol-2-yl)phenoxy)-2-butanol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared according to the method as described in Example 24b) from 2-(4-hydroxyphenyl)thiazole (1 g), ethanol (20 ml), sodium hydroxide (0.255 g), water (5 ml) and (±)-α-(chloromethyl)-3-pyridinepropanol (1 g, from Example 24a)) to give the title compound after purification as a white solid (0.42 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c5d261493cdc4369a10e098ff8a4abb3
Source dataset
uspto-grants-1999_11
Patent number
US05977105

Reaction notes

Loading…