4-Hydroxybenzophenone → HCID 21830698, compound

HRID 1600958Notes

Reaction equation

HRID 1600958 reaction equation
Cl[CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.[OH:13][C:14]1[CH:27]=[CH:26][C:17]([C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:19])=[CH:16][CH:15]=1.[OH-].[Na+]>C(O)C>[C:18]([C:17]1[CH:16]=[CH:15][C:14]([O:13][CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]2[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=2)=[CH:27][CH:26]=1)(=[O:19])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 143474-HydroxybenzophenoneHCID 14798Sodium HydroxideHCID 22465338HCID 22465338, compound

Product 1

HCID 21830698HCID 21830698, compoundYield 21.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared according to the method described in Example 24b) from (±)-α-(chloromethyl)-3-pyridinepropanol (1.05 g), 4-hydroxybenzophenone (1.35 g), ethanol (30 ml) and aqueous sodium hydroxide (1.4 M, 5 ml). After work up the residue was purified by column chromatography over silica with ether then ethyl acetate to give the title compound as an oil (0.42 g).

Workup

  1. customPrepared
  2. customAfter work up the residue was purified by column chromatography over silica with ether

Sources & evidence

ORD record
ord-cf7a482de135439c827cb460735e48a4
Source dataset
uspto-grants-1999_11
Patent number
US05977105

Reaction notes

Loading…