(1,1'-Biphenyl)-2-ol → HCID 21830695, compound

HRID 1600975Notes

Reaction equation

HRID 1600975 reaction equation
Cl[CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.[C:13]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[OH:25])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[OH-].[Na+]>C(O)C>[C:19]1([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 7017(1,1'-Biphenyl)-2-olHCID 14798Sodium HydroxideHCID 22465338HCID 22465338, compound

Product 1

HCID 21830695HCID 21830695, compoundYield 34.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared according to the method described in Example 24b) from (±)-α-(chloromethyl)-3-pyridinepropanol (1.0 g, Example 24a), 2-phenylphenol (0.92 g), ethanol (45 ml) and aqueous sodium hydroxide (1.0 M, 5 ml) with heating at reflux for 1 hour. After work up the residue was purified by column chromatography over silica eluting with hexane:acetone (2:1) to give the title compound as a colourless oil (0.60 g).

Workup

  1. customPrepared
  2. temperaturewith heating
  3. temperatureat reflux for 1 hour
  4. customAfter work up the residue was purified by column chromatography over silica eluting with hexane:acetone (2:1)

Sources & evidence

ORD record
ord-238b56f2bcf74416ad87c7a012487415
Source dataset
uspto-grants-1999_11
Patent number
US05977105

Reaction notes

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