HCID 15885172, compound → HCID 15885173, compound

HRID 1601028Notes

Reaction equation

HRID 1601028 reaction equation
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][N:10]([O:14][C:15](=[O:20])[C:16]([F:19])([F:18])[F:17])[CH2:11]2)=[CH:6][CH:5]=1)([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][N:10]([O:14][C:15](=[O:20])[C:16]([F:19])([F:17])[F:18])[CH2:11]2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 15885172HCID 15885172, compound

Product 1

HCID 15885173HCID 15885173, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 7-nitro-2-trifluoroacetoxy-1,2,3,4-tetrahydroisoquinoline (Stokker, Tetrahedron Letts., 1996, 37, 5453; 3.64 g, 13.3 mmol) in 100 mL EtOH at room temperature was was purged with argon and 10% palladium on carbon (300 mg) added. The mixture was then stirred under an atmosphere of hydrogen gas for 2 h. then filtered and the solvent removed in vacuo to yield a white solid which was sufficiently pure for use in the next step.

Workup

  1. additionadded
  2. filtrationthen filtered
  3. customthe solvent removed in vacuo
  4. customto yield a white solid which

Sources & evidence

ORD record
ord-2bb48eaae7b04a66be7b2ba20f497277
Source dataset
uspto-grants-1999_11
Patent number
US05977134

Reaction notes

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