Sodium borohydride → HCID 15885181, compound

HRID 1601036Notes

Reaction equation

HRID 1601036 reaction equation
[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([Br:15])[CH:13]=2)[CH2:8][CH2:7][N:6]=1)[CH2:2][CH2:3][CH3:4].[BH4-].[Na+]>CCO>[CH2:1]([CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([Br:15])[CH:13]=2)[CH2:8][CH2:7][NH:6]1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 15885180HCID 15885180, compound

Product 1

HCID 15885181HCID 15885181, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The imine from Step 2 was dissolved in absolute EtOH (25 mL) and NaBH4 (0.303 g, 8.0 mmol) was added. After 2 h, the solvent was removed and the residue treated with 1N HCL. Conc. NH40H was added to the solution which was then extracted with CH2Cl2 (3×), washed with brine, dried and concentrated to give the title compound as a viscous oil which was used as such.

Workup

  1. customthe solvent was removed
  2. additionthe residue treated with 1N HCL
  3. additionConc. NH40H was added to the solution which
  4. extractionwas then extracted with CH2Cl2 (3×)
  5. washwashed with brine
  6. customdried
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-a179283fd734466ebd8904edd573c6a0
Source dataset
uspto-grants-1999_11
Patent number
US05977134

Reaction notes

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