反应详情

A solution of 6-bromo-3,4-dihydro-1(1H)-isoquinolinone (Example 31, Step 1; 5.5 g, 1.0 mmol) in THF (25 mL) was treated with 1M BH3 in THF (5 mL, 5 mmol) and heated at reflux for 20 h. To the mixture was added MeOH (5 mL), the solvent removed and the residue heated with 2N HCl for 3 h. The reaction was cooled, made basic with aqueous NH4OH and extracted with CH2Cl2, dried and evaporated to give the title compound as a gum which was used as such.

1. temperatureat reflux for 20 h
2. customthe solvent removed
3. temperaturethe residue heated with 2N HCl for 3 h
4. temperatureThe reaction was cooled
5. extractionextracted with CH2Cl2
6. customdried
7. customevaporated