HCID 54135925, compound → HCID 54042444, compound

HRID 1601087Notes

Reaction equation

HRID 1601087 reaction equation
N1C2C=CC=CC=2NC=1CN1C2C=CC=CC=2N=C1C[N:21]([CH3:43])[CH2:22][C:23]([C:25]1[CH:42]=[CH:41][C:28]([O:29][CH2:30][C:31]([O:33][CH2:34]C2C=CC=CC=2)=[O:32])=[CH:27][CH:26]=1)=[O:24]>CCOC(C)=O.CO>[CH3:43][NH:21][CH2:22][CH:23]([C:25]1[CH:26]=[CH:27][C:28]([O:29][CH2:30][C:31]([O:33][CH3:34])=[O:32])=[C:41]([O:29][CH2:30][C:31]([O:33][CH3:34])=[O:32])[CH:42]=1)[OH:24]

Participants

4

Reactant 1

HCID 54135925HCID 54135925, compound

Product 1

HCID 54042444HCID 54042444, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Following the procedure of Example 76(e), except substituting dimethyl 4-[2-(Cbz-methylamino)acetyl]-1,2-phenylenedioxydiacetate (2.1 g, 4.57 mmol) for benzyl 4-[2-[[[1-[(benzimidazol-2-yl)methyl]benzimidazol-2-yl]methyl]methylamino]acetyl]phenoxyacetate and using EtOAc (50 mL) and MeOH (20 mL) as solvents, the title compound (1.34 g, 90%) was prepared: MS (ES) m/e 328.0 [M+H]+.

Sources & evidence

ORD record
ord-eeb9d8b2422a49e3af8e4c45038c0ded
Source dataset
uspto-grants-1999_11
Patent number
US05977101

Reaction notes

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