反应详情

温度

5 °C

To a suspension of the methyl 1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine-6-carboxylate (200 mg, 0.624 mmol) in THF (40 ml) cooled to 5° C. with ice bath was added potassium trimethylsilanoate (80.1 mg, 0.62 mmol). After stirring for 20 mins at 5° C., the reaction mixture was concentrated. The resulting residue was dissolved in 7 ml of DMAC and purified via reversed phase column eluted with 5-75% 0.1% TFA H2O and 0.1% TFA ACN to afford the desired product (100 mg, 66%).

1. concentrationthe reaction mixture was concentrated
2. dissolutionThe resulting residue was dissolved in 7 ml of DMAC
3. custompurified via reversed phase column
4. washeluted with 5-75% 0.1% TFA H2O and 0.1% TFA ACN