反应详情

A stirred suspension of (±)-2-(acetylamino)-5-phenyl-pentanoic acid (0.5003 g, 0.002126 mol) in 2.8 M hydrochloric acid was refluxed for 2 hours, and the resulting brown solution was allowed to cool. A tan precipitate formed upon cooling. The solids were filtered off, and the filtrate was rotary evaporated to give a yellow gum. The gum was dissolved in hot water, gravity filtered, and allowed to cool. The mixture was made basic with 1 M sodium hydroxide to pH=5. The resulting precipitate was filtered off, washed with water, and dried in vacuo to give a yellow solid; yield 0.205 g (50%), mp=213-215° C.

1. temperaturewas refluxed for 2 hours
2. temperatureto cool
3. customA tan precipitate formed
4. temperatureupon cooling
5. filtrationThe solids were filtered off
6. customthe filtrate was rotary evaporated
7. customto give a yellow gum
8. filtrationgravity filtered
9. temperatureto cool
10. filtrationThe resulting precipitate was filtered off
11. washwashed with water
12. customdried in vacuo
13. customto give a yellow solid