反应详情

To a suspension of sodium hydride (60% oil dispersion) (15.4 g) in 90 mL of 1,3-dimethyl-3,4,5,6-tetrahydro-2[1H]-pyrimidinone (DMPU), cooled in an ice-water bath, was added dropwise a solution of dimethyl malonate (44 mL) in DMPU (150 mL). The mixture was stirred 20 minutes after the addition was completed, and then 1-iodo-2 -[(2-methylphenoxy)methyl]benzene (62.5 g) and cuprous iodide (73.3 g) were added. The resulting mixture was stirred at 100° C. for 5 h, then stirred at 25° C. overnight. The mixture was diluted with 1 N. HCl (~150 mL) and extracted with diethyl ether (3×400 mL). The combined organic extracts were dried (MgSO4), filtered and concentrated under reduced pressure to a semi-solid, which was purified by flash chromatography on silica get (5:2 hexane:ethyl acetate as eluant). The major material was collected and concentrated to a white solid, which was triturated in hexane and collected by filtration to yield 56.9 g (79% of the title compound of Step C as a white solid, mp 99-103° C.

1. temperaturecooled in an ice-water bath
2. additionafter the addition
3. stirringThe resulting mixture was stirred at 100° C. for 5 h
4. stirringstirred at 25° C. overnight
5. additionThe mixture was diluted with 1 N
6. extractionHCl (~150 mL) and extracted with diethyl ether (3×400 mL)
7. dry with materialThe combined organic extracts were dried (MgSO4)
8. filtrationfiltered
9. concentrationconcentrated under reduced pressure to a semi-solid, which
10. customwas purified by flash chromatography on silica
11. customget (5:2 hexane:ethyl acetate as eluant)
12. customThe major material was collected
13. concentrationconcentrated to a white solid, which
14. customwas triturated in hexane
15. filtrationcollected by filtration