Sulfuric Acid → HCID 86754743, compound

HRID 1601151Notes

Reaction equation

HRID 1601151 reaction equation
[NH2:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][N:18]2[C:22]([C:23](O)([CH3:27])[C:24]([OH:26])=[O:25])=[C:21]([S:29][CH3:30])[N:20]=[C:19]2[CH2:31][CH2:32][CH2:33][CH3:34])=[CH:13][CH:12]=1)(=[O:4])=[O:3].O1CCOCC1.S(=O)(=O)(O)O.C(Cl)(Cl)Cl>O.[Na+].[Cl-].CO>[NH2:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:12]=[CH:13][C:14]([CH2:17][N:18]2[C:22]([C:23](=[CH2:27])[C:24]([OH:26])=[O:25])=[C:21]([S:29][CH3:30])[N:20]=[C:19]2[CH2:31][CH2:32][CH2:33][CH3:34])=[CH:15][CH:16]=1)(=[O:4])=[O:3]

Participants

8

Reactant 4

HCID 1118Sulfuric AcidHCID 6212ChloroformHCID 312751,4-DioxaneHCID 86754744HCID 86754744, compound

Product 1

HCID 86754743HCID 86754743, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 5234Sodium ChlorideSolvent

Procedure

1 g of the product obtained in Stage A above is introduced into 50 cm3 of dioxane and 5 cm3 of concentrated sulphuric acid is added. The solution is heated for about 5 hours, diluted with water, saturated with NaCl and extraction is carried out with CHCl3 with 20% MeOH.

Workup

  1. additionis added
  2. temperatureThe solution is heated for about 5 hours

Sources & evidence

ORD record
ord-8bca80b0445a4a77afdd7cf8d0022cb6
Source dataset
uspto-grants-1999_11
Patent number
US05977155

Reaction notes

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