Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 21831496 | HCID 21831496 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21831587 | HCID 21831587 | — |
Reaction Steps
5 g of 3-sulfonylamino-4-methoxyphenylacetic acid were dissolved in 3 ml of DMF and stirred at 40° C. for 30 minutes with 245 mg of sodium hydroxide. 328 mg of methyl isothiocyanate were added thereto and the mixture was stirred for a further 2 h at 70° C. 2N hydrochloric acid was added to the cooled solution and the product was filtered off with suction. M.p. 1740° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05977177 |
|---|
| Source dataset | uspto-grants-1999_11 |
|---|
| ORD ID | ord-b616a82410a446a991f0f20a190e1c8f |
|---|
| Source note | uspto-grants-1999_11 |
|---|
