Hydrochloric Acid → HCID 21831587, compound

HRID 1601335Notes

Reaction equation

HRID 1601335 reaction equation
[S:1](=[N:4][C:5]1[CH:6]=[C:7]([CH2:13][C:14]([OH:16])=[O:15])[CH:8]=[CH:9][C:10]=1[O:11][CH3:12])(=[O:3])=[O:2].[OH-].[Na+].[CH3:19]N=C=S.Cl>CN(C=O)C>[S:1](=[N:4][C:5]1[CH:6]=[C:7]([CH2:13][C:14]([OH:16])=[O:15])[CH:8]=[CH:9][C:10]=1[O:11][CH2:12][CH3:19])(=[O:2])=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 11167Methyl isothiocyanateHCID 14798Sodium HydroxideHCID 21831496HCID 21831496, compound

Product 1

HCID 21831587HCID 21831587, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
70 °C

Procedure

5 g of 3-sulfonylamino-4-methoxyphenylacetic acid were dissolved in 3 ml of DMF and stirred at 40° C. for 30 minutes with 245 mg of sodium hydroxide. 328 mg of methyl isothiocyanate were added thereto and the mixture was stirred for a further 2 h at 70° C. 2N hydrochloric acid was added to the cooled solution and the product was filtered off with suction. M.p. 1740° C.

Workup

  1. filtrationthe product was filtered off with suction

Sources & evidence

ORD record
ord-b616a82410a446a991f0f20a190e1c8f
Source dataset
uspto-grants-1999_11
Patent number
US05977177

Reaction notes

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