Ethyl 6-(2,2,3,3-tetrafluoropropoxy)nicotinate → [6-(2,2,3,3-Tetrafluoropropoxy)pyridin-3-yl]methanol

HRID 1601377Notes

Reaction equation

HRID 1601377 reaction equation
[F:1][C:2]([F:19])([CH:16]([F:18])[F:17])[CH2:3][O:4][C:5]1[CH:15]=[CH:14][C:8]([C:9](OCC)=[O:10])=[CH:7][N:6]=1.[H-].C([Al+]CC(C)C)C(C)C>>[F:19][C:2]([F:1])([CH:16]([F:18])[F:17])[CH2:3][O:4][C:5]1[CH:15]=[CH:14][C:8]([CH2:9][OH:10])=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 18363323Ethyl 6-(2,2,3,3-tetrafluoropropoxy)nicotinateHCID 21225700Diisobutylaluminumhydride

Product 1

HCID 18363303[6-(2,2,3,3-Tetrafluoropropoxy)pyridin-3-yl]methanolYield 100%

Procedure

Ethyl 6-(2,2,3,3-tetrafluoropropoxy)nicotinate was reduced with diisobutyl aluminum hydride in the same manner as in Reference example 21 to obtain the title compound as an oil in a yield of 100%.

Sources & evidence

ORD record
ord-7a07edd84fc148859b3ded99d171ad2f
Source dataset
uspto-grants-1999_11
Patent number
US05977152

Reaction notes

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