Propylene Oxide → Gadoteridol

HRID 1601642Notes

Reaction equation

HRID 1601642 reaction equation
[Na+].[N:2]1([CH2:22][C:23]([O-:25])=[O:24])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][N:8]([CH2:14][C:15]([O-:17])=[O:16])[CH2:7][CH2:6][N:5]([CH2:18][C:19]([O-:21])=[O:20])[CH2:4][CH2:3]1.[Na+].[Na+].[CH2:28]1[O:31][CH:29]1[CH3:30].[Gd:32]>>[CH3:28][CH:29]([OH:31])[CH2:30][N:11]1[CH2:10][CH2:9][N:8]([CH2:14][C:15]([O-:17])=[O:16])[CH2:7][CH2:6][N:5]([CH2:18][C:19]([O-:21])=[O:20])[CH2:4][CH2:3][N:2]([CH2:22][C:23]([O-:25])=[O:24])[CH2:13][CH2:12]1.[Gd+3:32]

Participants

4

Reactant 3

HCID 6378Propylene OxideHCID 23982GadoliniumHCID 108625271,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid trisodium salt

Product 1

HCID 60714Gadoteridol

Procedure

The solution of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid sodium salt is directly reacted, as described in EP 292689, with propylene oxide to give the alkylated product, which can easily be complexed with gadolinium to give the final Gadoteridol.

Workup

  1. customto give the alkylated product, which

Sources & evidence

ORD record
ord-b8c2b92330a14aa49e05781c3b6833d4
Source dataset
uspto-grants-1999_11
Patent number
US05977353

Reaction notes

Loading…