HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propylene Oxide → Gadoteridol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propylene Oxide | HCID 6378 | — |
| Reactant | Gadolinium | HCID 23982 | — |
| Reactant | 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid trisodium salt | HCID 10862527 | — |
| Product | Gadoteridol | HCID 60714 | — |
Reaction Steps
The solution of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid sodium salt is directly reacted, as described in EP 292689, with propylene oxide to give the alkylated product, which can easily be complexed with gadolinium to give the final Gadoteridol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977353 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-b8c2b92330a14aa49e05781c3b6833d4 |
| Source note | uspto-grants-1999_11 |