Hydrochloric Acid → 2,4-Difluoroaniline hydrochloride

Participants

Reaction Steps

First a suitable glass-lined reactor is charged with 484.7 lbs. of water, and then with 257.8 lbs. of 32% hydrochloric acid. While maintaining the temperature at less than 30° C., 116.8 lbs. of 2,4-difluoroaniline is added to the hydrochloric acid solution to form a slurry of 2,4-difluoroaniline hydrochloride. The slurry is cooled to 20° C., and then 145.9 lbs. of bromine is added over a 50 minute period, thus maintaining the temperature at less than 45° C. The temperature is held between 20° C. and 45° C. for 30 minutes.

Provenance & Evidence