Hydrochloric Acid → 2,4-Difluoroaniline hydrochloride

HRID 1601746Notes

Reaction equation

HRID 1601746 reaction equation
[ClH:1].[F:2][C:3]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:4]=1[NH2:5]>O>[ClH:1].[F:2][C:3]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:4]=1[NH2:5]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 97092,4-Difluoroaniline

Product 1

HCID 218323052,4-Difluoroaniline hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

First a suitable glass-lined reactor is charged with 484.7 lbs. of water, and then with 257.8 lbs. of 32% hydrochloric acid. While maintaining the temperature at less than 30° C., 116.8 lbs. of 2,4-difluoroaniline is added to the hydrochloric acid solution to form a slurry of 2,4-difluoroaniline hydrochloride. The slurry is cooled to 20° C., and then 145.9 lbs. of bromine is added over a 50 minute period, thus maintaining the temperature at less than 45° C. The temperature is held between 20° C. and 45° C. for 30 minutes.

Workup

  1. additionFirst a suitable glass-lined reactor is charged with 484.7 lbs
  2. temperatureWhile maintaining the temperature at less than 30° C.

Sources & evidence

ORD record
ord-5e0c9a60e52d4bf5a4a1a42b72d76590
Source dataset
uspto-grants-1999_11
Patent number
US05977412

Reaction notes

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