Trifluoroacetic acid → HCID 23298342, compound

HRID 1601769Notes

Reaction equation

HRID 1601769 reaction equation
[N:1]1[C:2]([CH2:10][CH2:11][O:12][C:13]2[CH:45]=[CH:44][C:16]([CH2:17][CH:18]3[S:22][C:21](=[O:23])[N:20](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[C:19]3=[O:43])=[CH:15][CH:14]=2)=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.FC(F)(F)C(O)=O>C(Cl)Cl>[N:1]1[C:2]([CH2:10][CH2:11][O:12][C:13]2[CH:45]=[CH:44][C:16]([CH2:17][CH:18]3[S:22][C:21](=[O:23])[NH:20][C:19]3=[O:43])=[CH:15][CH:14]=2)=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23298294HCID 23298294, compound

Product 1

HCID 23298342HCID 23298342, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A procedure similar to that described in Example 2 was repeated, except that 0.94 g of 5-[4-{2-(imidazo[1,2-a]pyridin-2-yl)ethoxy}benzyl]-3-triphenylmethylthiazolidine-2,4-dione (prepared as described in Preparation 27), 4 ml of methylene chloride and 1 ml of trifluoroacetic acid were used, to give the title compound as a crude product. This product was purified by column chromatography through silica gel, using a 2:1 by volume mixture of hexane and ethyl acetate and subsequently a 1:2 by volume mixture of ethyl acetate and tetrahydrofuran, as the eluents, to give 287 mg of the title compound, melting at 205.9-207.0° C. (with decomposition).

Sources & evidence

ORD record
ord-1d243af3ae6f4c48a1dce9c36fddad7b
Source dataset
uspto-grants-1999_11
Patent number
US05977365

Reaction notes

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