Glycolic Acid → HCID 10849735, compound

HRID 1601859Notes

Reaction equation

HRID 1601859 reaction equation
[NH2:1][C:2]1[C:3]([NH:15][CH3:16])=[N:4][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:7]=1.[C:17]([OH:21])(=O)[CH2:18]O>>[OH:21][CH2:17][C:18]1[N:15]([CH3:16])[C:3]2=[N:4][C:5]([S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)=[CH:6][CH:7]=[C:2]2[N:1]=1

Participants

3

Reactant 2

HCID 757Glycolic AcidHCID 105137093-Amino-2-methylamino-6-phenylthiopyridine

Product 1

HCID 10849735HCID 10849735, compound

Procedure

A procedure similar to that described in Preparation 43 was repeated, except that 2.62. g of 3-amino-2-methylamino-6-phenylthiopyridine (prepared as described in Preparation 89) and 2.58 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a gradient elution method, with mixtures of ethyl acetate and methanol in ratios ranging from 50:1 to 10:1 by volume as the eluent, to give 1.80 g of the title compound, melting at 119-120° C.

Workup

  1. customA procedure similar to that described in Preparation 43
  2. customthat the product was purified by column chromatography through silica gel
  3. washa gradient elution method

Sources & evidence

ORD record
ord-cb965347e8b44beb8c716c26491254e9
Source dataset
uspto-grants-1999_11
Patent number
US05977365

Reaction notes

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