Edetate Sodium → Ethylenediaminetetraacetic Acid

HRID 1602040Notes

Reaction equation

HRID 1602040 reaction equation
[CH2:1]([CH2:11][N:12]([CH2:17][C:18]([O-:20])=[O:19])[CH2:13][C:14]([OH:16])=[O:15])[N:2]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][C:4]([O-:6])=[O:5].[Na+].[Na+].[OH-].[Na+].C(N(CC([O-])=O)CC([O-])=O)CN(CC([O-])=O)CC([O-])=O.[Na+].[Na+].[Na+].[Na+]>O>[CH2:1]([N:2]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][C:4]([OH:6])=[O:5])[CH2:11][N:12]([CH2:17][C:18]([OH:20])=[O:19])[CH2:13][C:14]([OH:16])=[O:15]

Participants

5

Reactant 3

HCID 6144Edetate SodiumHCID 8759EDTA disodium salt2×HCID 14798Sodium Hydroxide2×

Product 1

HCID 6049Ethylenediaminetetraacetic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Disodium edetate (3.6 g) and 0.8 g of sodium hydroxide were dissolved in 170 mL of water. Polyethylene glycol 3350 (213 g) was added to this solution and dissolved. The sodium hydroxide facilitates the dissolution of the disodium edetate in the aqueous polyethylene glycol, through formation of the tetrasodium salt of EDTA. The polyethylene glycol solution was added to the drug-resin complex suspension and mixed well. The resulting mixture was dried in a fluid bed dryer by passing warm air through the wet polyethylene glycol treated drug resin complex at a sufficient velocity to suspend the material being dried. The inlet air temperature was 25 to 50C. and the mixture was dried to a moisture content of 6 to 10% by weight. This drying resulted in an EDTA concentration of about 0.36% by weight.

Workup

  1. dissolutiondissolved
  2. additionmixed well
  3. customThe resulting mixture was dried in a fluid bed dryer
  4. temperatureby passing warm air through the wet polyethylene glycol treated drug resin complex at a sufficient velocity
  5. custombeing dried
  6. customand the mixture was dried to a moisture content of 6 to 10% by weight

Sources & evidence

ORD record
ord-17eace1ae3964d1da9bdb23d02989c55
Source dataset
uspto-grants-1999_11
Patent number
US05980882

Reaction notes

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