Edetate Sodium → Ethylenediaminetetraacetic Acid

Participants

Reaction Steps

Disodium edetate (3.6 g) and 0.8 g of sodium hydroxide were dissolved in 170 mL of water. Polyethylene glycol 3350 (213 g) was added to this solution and dissolved. The sodium hydroxide facilitates the dissolution of the disodium edetate in the aqueous polyethylene glycol, through formation of the tetrasodium salt of EDTA. The polyethylene glycol solution was added to the drug-resin complex suspension and mixed well. The resulting mixture was dried in a fluid bed dryer by passing warm air through the wet polyethylene glycol treated drug resin complex at a sufficient velocity to suspend the material being dried. The inlet air temperature was 25 to 50C. and the mixture was dried to a moisture content of 6 to 10% by weight. This drying resulted in an EDTA concentration of about 0.36% by weight.

Provenance & Evidence