Sulfuric Acid → HCID 19609787, compound

HRID 1602075Notes

Reaction equation

HRID 1602075 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[F:8][C:9]([F:34])([F:33])[O:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]2[C:21]([NH:22][C:23]3[CH:28]=[C:27]([F:29])[C:26]([C:30]#[N:31])=[CH:25][C:24]=3[F:32])=[N:20][N:19]=[N:18]2)=[CH:13][CH:12]=1.S(=O)(=O)(O)O>>[F:34][C:9]([F:8])([F:33])[O:10][C:11]1[CH:12]=[CH:13][C:14]([N:17]2[C:21]([N:22]([C:1](=[O:3])[CH3:2])[C:23]3[CH:28]=[C:27]([F:29])[C:26]([C:30]#[N:31])=[CH:25][C:24]=3[F:32])=[N:20][N:19]=[N:18]2)=[CH:15][CH:16]=1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 19609803HCID 19609803, compound

Product 1

HCID 19609787HCID 19609787, compound

Procedure

A mixed solution of acetic anhydride (15 ml), 1-(4-trifluoromethoxyphenyl)-5-(4-cyano-2,5-difluoroanilino)tetrazole (1.5 g) and concentrated sulfuric acid (1 ml) was stirred at 70 to 80° C. for 1 hour. After unreacted acetic anhydride was distilled off under reduced pressure, the residue was washed with water and n-hexane to obtain 1-(4-trifluoromethoxyphenyl)-5-(4-cyano-2,5-difluoro-N-acetylanilino)tetrazole (1.55 g).

Workup

  1. distillationAfter unreacted acetic anhydride was distilled off under reduced pressure
  2. washthe residue was washed with water and n-hexane

Sources & evidence

ORD record
ord-a6be274bb0744dbfab40a3a38293d5a3
Source dataset
uspto-grants-1999_11
Patent number
US05981438

Reaction notes

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