Hydrogen Bromide → 1,3-Di-n-butyl-8-bromo Xanthine

HRID 1602141Notes

Reaction equation

[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([N+]([O-])=O)=[N:10][C:9]=2[N:8]([CH2:19][CH2:20][CH2:21][CH3:22])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4].[BrH:23]>>[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([Br:23])=[N:10][C:9]=2[N:8]([CH2:19][CH2:20][CH2:21][CH3:22])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 99444751,3-Di-n-butyl-8-nitro Xanthine

Product 1

HCID 101544891,3-Di-n-butyl-8-bromo Xanthine

Procedure

1,3-Di-n-butyl-8-bromo xanthine was prepared from 1,3-di-n-butyl-8-nitro xanthine (0.5 g, 0.0016 mol) and concentrated hydrobromic acid (8 ml) using the procedure as described in Example 15. The title product was obtained after recrystallisation from ethanol, yield 0.4 g (91%), m.pt. 178° C.

Sources & evidence

ORD record: ord-3034a768500e4b12980b698e15dcde54
Source dataset: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05981535

Reaction notes

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