Cyclopropanecarbonyl chloride → HCID 19610268, compound

HRID 1602168Notes

Reaction equation

[CH:1]1([CH:4]2[C:13]3[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=3)[CH2:7][CH2:6][NH:5]2)[CH2:3][CH2:2]1.COCC(Cl)=O.[CH:24]1(C(Cl)=O)[CH2:26][CH2:25]1>>[CH2:1]([CH:4]1[C:13]2[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=2)[CH2:7][CH2:6][NH:5]1)[CH2:3][CH2:2][CH2:25][CH2:24][CH3:26]

Participants

Reactant 3

HCID 77637Cyclopropanecarbonyl chloride

HCID 96623Methoxyacetyl chloride

HCID 196102151-Cyclopropyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 19610268HCID 19610268, compound

Procedure

1,2,3,4-Tetrahydro-1-hexyl-6,7-dimethoxyisoquinoline was prepared by a procedure analogous to that described in example 4 for 1,2,3,4-tetrahydro-1-cyclopropyl-6,7- dimethoxyisoquinoline but substituting in the first step 2-methoxyacetyl chloride for cyclopropylcarbonyl chloride.

Sources & evidence

ORD record: ord-78f9a4b227db4e118ba7a022151bf3db
Source dataset: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05981521

Reaction notes

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