Oxalyl chloride → HCID 19610235, compound

Temperature

10 °C

To a solution of N-acetyl-O-methyltyrosine methyl ester (10 g, 39.8 mmol) in anhydrous dichloromethane (350 mL) was added oxalyl chloride (44 mL, 2 M solution). The reaction mixture was stirred for 1 hr and then cooled to - 10° C. and to it anhydrous iron (III) trichloride (7.75 g, 47.8 mmol) was added portionwise. The stirring was continued overnight at room temperature and then the reaction mixture was treated with 2 M HC1 (100 mL) for 2 hrs. The organic phase was separated, washed with water and brine, dried (MgSO4) and concentrated in vacuo. Methanol (130 mnL) and concentrated sulfuric acid (6 niL) were added to the foamy residue and reaction was heated to reflux for 8 hrs. The reaction mixture was concentrated in vacuo, diluted with water (100 mL) and extracted with ethyl acetate (2×50 mL). The water layer was basified with ammonium hydroxide to pH >9 and extracted with dichloromethane (3×50 mL). The organic phase was washed with water, brine, dried (MgSO4) and concentrated in vacuo. The dark yellow product (8.7 g) was purified by a silica gel column chromatography eluting with (1: 1) ethyl acetate/ hexane to yield 5.61 g (60 %) of yellow product: 1H-NMR (CDCl3, δ): 2.45 (d, J=2 Hz, 3H), 2.82- 3.00 (m. 2H), 3.82 (s, 3H), 3.83 (s, 3H), 4.19 (qq. J=2. 6.8 Hz, I H), 6.93 (dd, J=2.7, 7.5 Hz, 1H), 7.05 (d, J=2.7 Hz, 1H), 7.14 (d, J=7.5 Hz- 1H): MS showed (M+H) +@ 234; Anal. Calcd for C13H15NO3 : C, 66.94; H, 6.48; N, 6.00; Found: C, 66.78; H, 6.36; N, 5.96.

1. waitThe stirring was continued overnight at room temperature
2. additionthe reaction mixture was treated with 2 M HC1 (100 mL) for 2 hrs
3. customThe organic phase was separated
4. washwashed with water and brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated in vacuo
7. additionMethanol (130 mnL) and concentrated sulfuric acid (6 niL) were added to the foamy residue and reaction
8. temperaturewas heated
9. temperatureto reflux for 8 hrs
10. concentrationThe reaction mixture was concentrated in vacuo
11. additiondiluted with water (100 mL)
12. extractionextracted with ethyl acetate (2×50 mL)
13. extractionextracted with dichloromethane (3×50 mL)
14. washThe organic phase was washed with water, brine
15. dry with materialdried (MgSO4)
16. concentrationconcentrated in vacuo
17. customThe dark yellow product (8.7 g) was purified by a silica gel column chromatography
18. washeluting with (1: 1) ethyl acetate/ hexane

ORD record

ord-0a05646b3a07422b94e8b23a897fc5b6

Source dataset

uspto-grants-1999_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05981521