Hydrogen iodide → HCID 19610257, compound

HRID 1602178Notes

Reaction equation

HRID 1602178 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH:8]([C:14]([O:16][CH3:17])=[O:15])[NH:9][CH:10]2[CH3:13])=[CH:5][CH:4]=1.[IH:18]>CO>[IH:18].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH:8]([C:14]([O:16][CH3:17])=[O:15])[NH:9][CH:10]2[CH3:13])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24841Hydrogen iodideHCID 19610221HCID 19610221, compound

Product 1

HCID 19610257HCID 19610257, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1,2,3,4-tetrahydro-7-methoxy-3-methoxycarbonyl-1-methyl-isoquinoline (0.526 g, 2.24 mmol) in methanol (10 mL) cooled to 0° C. was added dropwise a solution of 57% HI solution (0.33 mL). The ice bath was removed and the solution was stirred at rt for 20 min. To the bright orange solution was added ether (100 mL) and the mixture was stirred for 10 min. The light yellow precipitate was filtered and dried in vacuo (P2O5) to give the desired salt (0.736 g).

Workup

  1. customThe ice bath was removed
  2. additionTo the bright orange solution was added ether (100 mL)
  3. stirringthe mixture was stirred for 10 min
  4. filtrationThe light yellow precipitate was filtered
  5. dry with materialdried in vacuo (P2O5)

Sources & evidence

ORD record
ord-1cd2963fbf374d3ea3ee276fbd69043d
Source dataset
uspto-grants-1999_11
Patent number
US05981521

Reaction notes

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