Trifluoroacetic acid → HCID 86754768, compound

HRID 1602189Notes

Reaction equation

HRID 1602189 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C@@H:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:17][CH:16]=2)[C@H:10]([O:28][CH2:29][CH2:30][O:31][CH3:32])[CH2:9]1)=O)(C)(C)C.[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36]>ClCCl>[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36].[O:21]([C:18]1[CH:17]=[CH:16][C:15]([O:14][C@@H:11]2[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]2[O:28][CH2:29][CH2:30][O:31][CH3:32])=[CH:20][CH:19]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86754766HCID 86754766, compound

Product 1

HCID 86754768HCID 86754768, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (±)-trans-N-tert-butoxycarbonyl-4-(4-phenoxyphenoxy)-3-(2-methoxy-1-ethoxy)piperidine (2.1 g, 4.7 mmol) in dry dichloromethane (20 ml) and trifluoroacetic acid (1.5 ml) was added. After 2 h the volatiles were evaporated. The residue was triturated with petroleum ether to leave the title compound as an oil. Yield 2.2 g 100%.

Workup

  1. customAfter 2 h the volatiles were evaporated
  2. customThe residue was triturated with petroleum ether

Sources & evidence

ORD record
ord-6248d266bbbc4d5a81ef26277d42a506
Source dataset
uspto-grants-1999_11
Patent number
US05981539

Reaction notes

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