Hydrazine hydrate (1:1) → HCID 178509386, compound

HRID 1602248Notes

Reaction equation

HRID 1602248 reaction equation
O.[NH2:2][NH2:3].[N+:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13](SC)=[C:14]([C:17]#[N:18])[C:15]#[N:16])=[CH:9][CH:8]=1)([O-:6])=[O:5]>CO>[NH2:16][C:15]1[NH:3][N:2]=[C:13]([C:10]2[CH:11]=[CH:12][C:7]([N+:4]([O-:6])=[O:5])=[CH:8][CH:9]=2)[C:14]=1[C:17]#[N:18]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 108479392-[(Methylthio)(4-nitrophenyl)methylene]propanedinitrile

Product 1

HCID 178509386HCID 178509386, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.05 ml (1.00 mmol) of hydrazine hydrate is added dropwise to 245.3 mg (1.00 mmol) of 3-(4-nitrophenyl)-3-methylmercapto-2-cyano-acrylonitrile in 1.3 ml of methanol and the reaction mixture is then boiled for 8 hours and then concentrated by evaporation. The residue is stirred with ethyl acetate and filtered, yielding 5-amino-3-(4-nitrophenyl)-1H-pyrazole-4-carbonitrile; TLC: Rf =0.14 (ethyl acetate:hexane=1:1).

Workup

  1. concentrationconcentrated by evaporation
  2. filtrationfiltered

Sources & evidence

ORD record
ord-af072172a9fd44da86791438ba281d08
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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