反应详情

0.05 ml (1.00 mmol) of hydrazine hydrate is added dropwise to 245.3 mg (1.00 mmol) of 3-(4-nitrophenyl)-3-methylmercapto-2-cyano-acrylonitrile in 1.3 ml of methanol and the reaction mixture is then boiled for 8 hours and then concentrated by evaporation. The residue is stirred with ethyl acetate and filtered, yielding 5-amino-3-(4-nitrophenyl)-1H-pyrazole-4-carbonitrile; TLC: Rf =0.14 (ethyl acetate:hexane=1:1).

1. concentrationconcentrated by evaporation
2. filtrationfiltered